Truan munro biography of martin

For extensive list of connections in the Indian Film Industry, see List of Indian film clans.

This is a list of contemporary (20th- or 21st-century) show business families.

This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

Families

A

Adams-Beaver

Aday

• Musician and part-time actor Michael Lee Aday (born Marvin Lee Aday), better known by his stage name of Meat Loaf, was the father of singer Pearl Aday and actress Amanda Aday.

Affleck

Alba/Warren

Alda

Aldridge

Allen

Allen

Allen/Rashād

Allman

Aniston-Theroux

Apatow

Appleton

Arden-Osbourne

• Music manager and agent Don Arden was the father of Sharon Osbourne (see Osbourne), the wife and manager of heavy metal icon Ozzy Osbourne. Sharon entered the public consciousness for the first time with the success of the reality TV show The Osbournes.
  • The oldest of Ozzy and Sharon's children, Aimee Osbourne, chose not to appear on The Osbournes; she is an actress, singer, and writer. Her two younger siblings did appear on the show; Kelly is an actress and singer, and Jack is a director and producer.

Arkin

• Actor/composer Alan Arkin, father of actors Adam, Matthew, and Anthony Arkin.
  • Adam is the father of Molly Arkin.

Armendáriz-Marín

Arnold-Jones

Arquette-Cox

Asher

Asher-Bulifant

• William Asher, television actor, was born to stage actress Lillian Bonner and producer Ephraim M. Asher. His sister, Betty Asher, was an MGM publicist for Judy Garland. William was married to actress Danny Sue Nolan. Later he was married to actress Elizabeth Montgomery (see Montgomery) and they have daughter, Rebecca Asher, a film editor, and son and guitar maker, Bill Asher. Finally he married actress Joyce Bulifant (see Bulifant). He adopted Bulifant's son, actor John Asher, born to actor Edward Mallory (see Mallory).

Asti

Abstract

Many personality traits are influenced by genetic factors. Rodents models provide an efficient system for analyzing genetic contribution to these traits. Using 1,246 adolescent heterogeneous stock (HS) male and female rats, we conducted a genome-wide association study (GWAS) of behaviors measured in an open field, including locomotion, novel object interaction, and social interaction. We identified 30 genome-wide significant quantitative trait loci (QTL). Using multiple criteria, including the presence of high impact genomic variants and co-localization of cis-eQTL, we identified 17 candidate genes (Adarb2, Ankrd26, Cacna1c, Cacng4, Clock, Ctu2, Cyp26b1, Dnah9, Gda, Grxcr1, Eva1a, Fam114a1, Kcnj9, Mlf2, Rab27b, Sec11a, and Ube2h) for these traits. Many of these genes have been implicated by human GWAS of various psychiatric or drug abuse related traits. In addition, there are other candidate genes that likely represent novel findings that can be the catalyst for future molecular and genetic insights into human psychiatric diseases. Together, these findings provide strong support for the use of the HS population to study psychiatric disorders.

Keywords: GWAS, outbred, anxiety, open field, novelty-seeking, social interaction, heterogeneous stock, rats

1. Introduction

Many personality traits are predictors of vulnerability to addiction (1). For example, individuals with symptoms of anxiety are more likely to be smokers (2, 3), and novelty seeking is positively correlated with both smoking onset (4) and cocaine abuse (5). In addition, the social environment plays a critical role in the development and treatment of addiction (6). Many of these phenomena can be modeled using rodents to unveil their neural, genetic, and molecular mechanisms (7–10).

The open-field test (OFT) is a widely used behavioral test for measuring anxiety-like and exploratory behavior in rodents (11–14). A rodent is typically placed in an open chamber surrounded by tall walls. Vi

Published in final edited form as: Biochemistry. 2011 Sep 6;50(39):8333–8341. doi: 10.1021/bi201099j

Abstract

Identifying key structural features of cytochromes P450 is critical in understanding the catalytic mechanism of these important drug-metabolizing enzymes. Cytochrome P450BM-3 (BM-3), a structural and mechanistic P450 model, catalyzes the regio- and stereoselective hydroxylation of fatty acids. Recent work has demonstrated the importance of water in the mechanism of BM-3, and site- specific mutagenesis has helped to elucidate mechanisms of substrate recognition, binding, and product formation. One of the amino acids identified as playing a key role in the active site of BM-3 is alanine 328, which is located in the loop between the K helix and β 1–4. In the A328V BM-3 mutant, substrate affinity increases 5 to 10-fold and the turnover number increases 2 to 8-fold compared to wild-type enzyme. Unlike wild-type enzyme, this mutant is purified from E. coli with endogenous substrate bound due to the higher binding affinity. Close examination of the crystal structures of the substrate-bound native and A328V mutant BMPs indicate that the positioning of the substrate is essentially identical in the two forms of the enzyme, with the two valine methyl groups occupying voids present in the active site of the wild-type substrate-bound structure.

Keywords: Cytochrome P450, Heme, P450BM-3, CYP102A1, Substrate binding, Spin-state, Protein structure

More than 65 years after the original description of pigments in microsomes isolated from liver by Albert Claude in 1943 (1), cytochrome P450 biochemistry remains a very active area of research. The enzymes are involved in a number of extremely important biochemical pathways, including but not limited to xenobiotic metabolism (including ‘Phase I’ drug metabolism), steroid hormone and bile acid biosynthesis, vitamin D metabolism, and the metabolism of numerous fatty

Mr. & Mrs. John V. Abbott

Mr. & Mrs. Stephen M. Abelman

Bill & Shelley Alexander 

Dr. & Mrs. Gregg P. Allen 

Teresa Corlew & Wes Allen 

Reed & Dianne Arvin 

Jeremy & Rebecca Atack 

Jon K. & Colleen Atwood 

Miss Lenai Augustine 

Grace & Carl Awh 

Sallie & John Bailey 

David Baldwin & Melissa K. Moss 

Mrs. Melinda S. & Dr. Jeffrey R. Balser 

Judy & Joe Barker 

J.E. & Doris Barlow 

Frank & Dina Basile 

Ned Bates & Brigette Anschuetz 

Mr. Russell W. Bates & Mr. Benjamin Scott 

Elisabetha Baugh* 

Michael V. and Sharry D. Beard 

Craig & Angela Becker 

Danny & Megan Bedford 

Dr.* & Mrs. Robert O. Begtrup 

Clara and Wesley Belden 

Dr. and Mrs. Randy Bellows 

Ms. Johnna Benedict Watson 

Mr. & Mrs. Douglas Bennett Jr. 

Mike & Kathy Benson 

Dr. Eric & Elaine Berg 

Mrs. Jean Bills 

Ms. Erin L. Bishop 

Celia Applegate & David Blackbourn 

Blevins, Inc. 

Ms. Dee W. Boaz 

Dr. & Mrs. Frank H. Boehm 

Dennis & Tammy Boehms 

Mr.* & Mrs. Roger Borchers 

Mr. & Mrs. Dennis Bottorff 

Jamey Bowen & Norman Wells 

H. Victor Braren, M.D. 

Robert & Barbara Braswell 

Mary Lawrence Breinig 

Dr. & Mrs. Phillip L. Bressman 

Pam Koerner & Mike Brown 

Mr. & Mrs. Steve R. Brubaker 

Mr. & Mrs. Scott Bryant 

Jean & David Buchanan 

Ann & Frank Bumstead 

Drs. Rodney & Janice Burt 

Anonymous 

David L. & Chigger J. Bynum 

Chuck & Sandra Cagle 

Mike & Jane Ann Cain 

Mr. and Mrs. Anthony Calderon 

Mrs. Julia C. Callaway 

Mary Taylor Gallagher & Chris Cardwell 

Sykes & Ann Cargile 

David L. Carlton 

Crom & Kathy Carmichael 

Tom & Kathi Carr 

Dr. Robert J. Carroll 

Mr. Michael Carter, Sr. & Mrs. Pamela Carter 

Anita & Larry Cash 

Fred Cassetty 

Ms. Ruth L. Cate & Mr. R. C. White 

Mary & Joseph Cavarra 

Anonymous 

David & Pam Chamberlin 

Erica &